Last seen wandering around university in US city (5)
I believe the answer is:
tulsa
'us city' is the definition.
(I've seen this before)
'last seen wandering around university' is the wordplay.
'seen wandering' is an anagram indicator (I've seen this in other clues).
'around' indicates putting letters inside.
'university' becomes 'U' (abbreviation as in UMass).
'last' is an anagram of 'tlsa'.
'tlsa' enclosing 'u' is 'TULSA'.
'in' is the link.
(Other definitions for tulsa that I've seen before include "US city" , "Oklahoma river port" , "Major oil centre" , "Twenty-four Hours from - (Gene Pitney)" , "A lust for the Oklahoma oil city?" .)