Last stop - overlooking Northern River (6)
I believe the answer is:
endure
'last' is the definition.
(synonyms)
'stop overlooking northern river' is the wordplay.
I cannot really see how this works, but
'stop' could be 'end' (synonyms) and 'end' is located in the answer.
'river' could be 'ure' (river in Yorkshire) and 'ure' is present in the answer.
This accounts for all the letters.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for endure that I've seen before include "Suffer or undergo" , "Bear, suffer" , "Go through" , "Last or tolerate" , "Last or bear with courage" .)