Last word associated with clever subject (8)
I believe the answer is:
amenable
'subject' is the definition.
(thesaurus)
'last word associated with clever' is the wordplay.
'last word' becomes 'amen' (last word in a prayer).
'associated with' is a charade indicator (letters next to each other).
'clever' becomes 'able' (able can mean skilled or talented).
'amen'+'able'='AMENABLE'
(Other definitions for amenable that I've seen before include "Easily influenced" , "Agreeable and accommodating" , "Compliant - persuadable" , "Acquiescent" , "Willing to comply" .)