Laundry is no longer opening for him (4)
I believe the answer is:
wash
'laundry' is the definition.
('wash' can be a synonym of 'laundry')
'is no longer opening for him' is the wordplay.
'is no longer' becomes 'was' (I've seen this before).
'opening for' indicates taking the first letters.
The first letter of 'him' is 'h'.
'was'+'h'='WASH'
(Other definitions for wash that I've seen before include "Scrub" , "put on thin coat" , "Rough water left by a moving boat" , "Laundry" , "Clean oneself" .)