Lay off from many new sites (6)
I believe the answer is:
desist
'lay off' is the definition.
(thesaurus)
'many new sites' is the wordplay.
'many' becomes 'd' ().
'new' indicates an anagram.
'sites' anagrammed gives 'esist'.
'd'+'esist'='DESIST'
'from' acts as a link.
(Other definitions for desist that I've seen before include "Stop, discontinue" , "Stop, abstain" , "Cease; abstain" , "Abstain, refrain" , "Whoa, cease" .)