Lay off the wine (4)
I believe the answer is:
sack
I believe this clue is a double definition.
'lay off' is the first definition.
(thesaurus)
'the wine' is the second definition.
(sack is a kind of wine)
(Other definitions for sack that I've seen before include "Elbow" , "A bag for Falstaff's drink" , "Discharge" , "present holder" , "Plunder - dry white wine - dismissal" .)