Laying off workers embarrassed humanitarian body — and shocked disheartened charity (10)
I believe the answer is:
redundancy
'laying off workers' is the definition.
'embarrassed humanitarian body and shocked disheartened charity' is the wordplay.
'embarrassed' becomes 'red' (I've seen this before).
'humanitarian body' becomes 'un' (I can't explain this - if you can you should believe this answer much more).
'shocked' indicates an anagram.
'disheartened' means to remove the middle letters.
'charity' with its centre removed is 'cy'.
'and' is an anagram of 'dan'.
'red'+'un'+'dan'+'cy'='REDUNDANCY'
(Other definitions for redundancy that I've seen before include "Dismissal" , "Surplus, especially in one's job!" , "Loss of job" .)