Lead guitarist in German city calls out for The Cure
I believe the answer is:
hangover
'calls out for the cure' is the definition.
I can't judge whether this definition defines the answer.
'lead guitarist in german city' is the wordplay.
'lead guitarist' becomes 'g' (I can't justify this - if you can you should believe this answer much more).
'in' is an insertion indicator.
'german city' becomes 'hanover' (I've seen this before).
'g' placed inside 'hanover' is 'HANGOVER'.
Can you help me to learn more?
(Other definitions for hangover that I've seen before include "morning-after feeling?" , "problem arising?" , "Something that has survived from the past" , "Morning after state following from 17 Across" , "a pain come the morning?" .)