Leaders cannot ignore constant annoying drone associated with loud insect (6)
I believe the answer is:
cicada
'loud insect' is the definition.
(I've seen this in another clue)
'leaders cannot ignore constant annoying drone associated' is the wordplay.
'leaders' says to take the initial letters.
The initial letters of 'cannot ignore constant annoying drone associated' is 'CICADA'.
'with' acts as a link.
(Other definitions for cicada that I've seen before include "Chirpy type" , "Insect, produces high-pitched drone" , "one that loves the heat" , "Chirpy little thing" , "Shrill insect" .)