Leaders of Home Office order cheap home-made booze (5)
I believe the answer is:
hooch
'booze' is the definition.
(thesaurus)
'leaders of home office order cheap home' is the wordplay.
'leaders of' suggests taking the first letters.
The initial letters of 'home office order cheap home' is 'HOOCH'.
'made' is the link.
(Other definitions for hooch that I've seen before include "Illicit alcohol" , "banned alcohol" , "moonshine" , "Illicitly distilled spirit" , "Illicit whisky" .)