Leading actor emptied venue fast (6)
I believe the answer is:
starve
'fast' is the definition.
(I've seen this before)
'leading actor emptied venue' is the wordplay.
'leading actor' becomes 'star' (I've seen this before).
'emptied' suggests removing the centre.
'venue' with its centre taken out is 've'.
'star'+'ve'='STARVE'
(Other definitions for starve that I've seen before include "Suffer from food deprivation" , "Vaster (anag)" , "Without wishing, fast" , "Suffer great hunger" , "Die from lack of food" .)