Leading by goal, change things drastically (5)
I believe the answer is:
upend
(Other definitions for upend that I've seen before include "Alter greatly" , "Make a turnover" , "change things drastically" , "Topple" , "Set upside down" .)
I believe the answer is:
upend
(Other definitions for upend that I've seen before include "Alter greatly" , "Make a turnover" , "change things drastically" , "Topple" , "Set upside down" .)