Leading couple in play given moderate cheer (6)
I believe the answer is:
please
'cheer' is the definition.
(thesaurus)
'leading couple in play given moderate' is the wordplay.
'leading' is a charade indicator (letters next to each other).
'couple in play given' becomes 'pl' (I am not sure about this - if you are sure you should believe this answer much more).
'moderate' becomes 'ease' (moderate can mean to relax or ease).
'pl' put next to 'ease' is 'PLEASE'.
Can you help me to learn more?
(Other definitions for please that I've seen before include "Beatles song (request to oblige?)" , "Polite word of request" , "Be good enough to" , "Like" , "Polite addition to a request" .)