Crossword Genius

Leading visitor, Virginia is most uncertain (7)

Ross

I believe the answer is:

vaguest

'most uncertain' is the definition.
(vague can mean uncertain)

'leading visitor virginia' is the wordplay.
'leading' says to put letters next to each other.
'visitor' becomes 'guest' (someone visiting a place).
'virginia' becomes 'va' (US state abbreviation).
'guest' after 'va' is 'VAGUEST'.

'is' acts as a link.

(Another definition for vaguest that I've seen is " Least precise".)

I've seen this clue in The Times.
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