Leave a region of India (3)
I believe the answer is:
goa
'region of india' is the definition.
(I've seen this in another clue)
'leave a' is the wordplay.
'leave' becomes 'go' (to go is to depart or leave).
'go'+'a'='GOA'
(Other definitions for goa that I've seen before include "Suitable place in India" , "State of India, a former Portuguese colony" , "State on west coast of India" , "Indian port" , "Indian resort" .)