Leave extremely disreputable character (6)
I believe the answer is:
depart
'leave' is the definition.
('depart' can be a synonym of 'leave')
'extremely disreputable character' is the wordplay.
'extremely' says to hollow out the word (remove centre letters).
'character' becomes 'part' ('part' can be a synonym of 'character'**).
'disreputable' with its centre taken out is 'de'.
'de'+'part'='DEPART'
(Other definitions for depart that I've seen before include "Take one's leave, go" , "Petard (anag.)" , "Prated (anag.)" , "make tracks" , "Make an exit" .)