Leave house less regularly (4)
I believe the answer is:
hols
'leave' is the definition.
(I've seen this before)
'house less regularly' is the wordplay.
'house' becomes 'ho' (abbreviation for house).
'regularly' indicates alternate letters (regularly take one letter, leave next etc.).
The alternating letters of 'less' are 'ls'.
'ho'+'ls'='HOLS'
(Other definitions for hols that I've seen before include "Time off school" , "Leave" , "vacation" .)