Leave huge foe to spread weed (9)
I believe the answer is:
goosefoot
'weed' is the definition.
The answer and definition can be both plants as well as being singular nouns.
Perhaps there's an association between them I don't understand?
'leave huge foe to spread' is the wordplay.
'leave' becomes 'go' (to go is to depart or leave).
'huge' becomes 'os' (abbreviation for outsize).
'spread' is an anagram indicator.
'foe'+'to'='foeto'
'foeto' with letters rearranged gives 'efoot'.
'go'+'os'+'efoot'='GOOSEFOOT'
Can you help me to learn more?
(Another definition for goosefoot that I've seen is " Plant of the beet family".)