Leave sweltering region? (6)
I believe the answer is:
desert
This might be a double definition.
'leave' is the first definition.
(desert can mean to leave or abandon)
'sweltering region?' is the second definition.
'desert' can be an answer for 'region?' (desert is a kind of region). I am unsure of the 'sweltering' bit.
Can you help me to learn more?
(Other definitions for desert that I've seen before include "Leave behind - waste" , "Abandon in barren terrain" , "Abandon; barren waste" , "Abandon in arid place" , "Defect, forsake" .)