Leave via Acton, unusually (8)
I believe the answer is:
vacation
'leave' is the definition.
(leave from one's job)
'via acton unusually' is the wordplay.
'unusually' indicates an anagram.
'via'+'acton'='viaacton'
'viaacton' anagrammed gives 'VACATION'.
(Other definitions for vacation that I've seen before include "Holiday period" , "Leave" , "Leisure time away from work" , "An American holiday" , "break" .)