Leave Virginia with American deer (7)
I believe the answer is:
vamoose
'leave' is the definition.
(vamoosing is a kind of leaving)
'virginia with american deer' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'with' is a charade indicator (letters next to each other).
'american deer' becomes 'moose' (I've seen this before).
'va'+'moose'='VAMOOSE'
(Other definitions for vamoose that I've seen before include "Sling your hook!" , "Depart hurriedly" , "vanish" , "Clear off" , "Dash off" .)