Leave Virginia with an elk (7)
I believe the answer is:
vamoose
'leave' is the definition.
(vamoosing is a kind of leaving)
'virginia with an elk' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'with' means one lot of letters go next to another.
'an elk' becomes 'moose' ('moose' can be a synonym of 'elk').
'va'+'moose'='VAMOOSE'
(Other definitions for vamoose that I've seen before include "Scram!" , "take flight!" , "Do a runner" , "Get going: leave hurriedly" , "Beat it" .)