Leave wife suppressing large flush (4)
I believe the answer is:
glow
'flush' is the definition.
(thesaurus)
'leave wife suppressing large' is the wordplay.
'leave' becomes 'go'.
'wife' becomes 'w'.
'suppressing' means one lot of letters goes inside another.
'large' becomes 'l'.
'go'+'w'='gow'
'gow' enclosing 'l' is 'GLOW'.
(Other definitions for glow that I've seen before include "rosy colour" , "Brightness" , "warmth of feeling" , "Give out steady light" , "Emit light and heat without flame" .)