Leaving home to be entertained by wine supply expert (6)
I believe the answer is:
boffin
'expert' is the definition.
'leaving home to be entertained by wine' is the wordplay.
'leaving home' becomes 'off' (off can mean going away).
'to be entertained by' means one lot of letters goes inside another (inserted letters are hosted or entertained).
'wine' becomes 'bin' (a bin is a type of container for wine).
'off' going into 'bin' is 'BOFFIN'.
'supply' is the link.
(Other definitions for boffin that I've seen before include "Research scientist" , "Brainbox" , "Technical researcher" , "Scientist (informal)" , "Back-room boy" .)