Left in charge, head for the hills (4)
I believe the answer is:
flee
'head for the hills' is the definition.
(I've seen this before)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for flee that I've seen before include "Run quickly away" , "Run (from danger)" , "Take to one's heels" , "head for the hills" , "rush" .)