Left with gout seizing one (4,3)
I believe the answer is:
gone out
'left' is the definition.
(going out is a kind of leaving)
'gout seizing one' is the wordplay.
'seizing' indicates putting letters inside.
'gout' enclosing 'one' is 'GONE OUT'.
'with' is the link.
(Other definitions for gone out that I've seen before include "On The Town possibly" , "dated" , "Having left the house (to go to a party?)" .)