Leg joint to irk, run being cancelled (5)
I believe the answer is:
ankle
'leg joint' is the definition.
(I've seen this before)
'irk run being cancelled' is the wordplay.
'irk' becomes 'rankle' (both can mean to annoy).
'run' becomes 'r' (cricket abbreviation).
'being cancelled' suggests deleting specific letters.
'rankle' with 'r' taken out is 'ANKLE'.
'to' is the link.
(Other definitions for ankle that I've seen before include "Foot-leg connector" , "Major joint in lower limb" , "Human joint" , "Leg-joint" , "Joint between foot and leg" .)