Leprous relative Jane edges away! (7)
I believe the answer is:
unclean
'leprous' is the definition.
Although both the answer and definition are adjectives, I can't see how they can define each other.
'relative jane edges away' is the wordplay.
'relative' becomes 'uncle' (uncle is a kind of relative).
'edges away' says to take the centre (I've seen 'edging away' mean this).
The middle letters of 'jane' are 'an'.
'uncle'+'an'='UNCLEAN'
Can you help me to learn more?
(Other definitions for unclean that I've seen before include "Ceremonially impure" , "Contaminated" , "Polluted" , "Defiled" , "Dirty, needs a wash" .)