Leslie, out of work, goes running (5)
I believe the answer is:
lopes
'goes running' is the definition.
Although both the answer and definition are verbs in their -s form, I cannot see how one could define the other.
'leslie out of work' is the wordplay.
'leslie' becomes 'les' (short for Leslie).
'out of' is an insertion indicator (some letters on the outside of others).
'work' becomes 'op' (abbreviation for opus).
'les' going around 'op' is 'LOPES'.
Can you help me to learn more?
(Other definitions for lopes that I've seen before include "Runs easily" , "Bounds" , "Runs using poles" , "Runs with long bounding steps" .)