Let guide them around empty site (6)
I believe the answer is:
leased
'let guide' is the definition.
'leased' can be an answer for 'let' (I've seen this in another clue). I am not sure about the 'guide' bit.
'them around empty site' is the wordplay.
'them' becomes 'lead' (I am not sure about this - if you are sure you should believe this answer much more).
'around' is an insertion indicator.
'empty' means to remove the middle letters.
'site' with its centre removed is 'se'.
'lead' going around 'se' is 'LEASED'.
Can you help me to learn more?
(Other definitions for leased that I've seen before include "Let for money" , "Rented" .)