Letter; fame (4)
I believe the answer is:
note
I believe this clue is a double definition.
'letter' is the first definition.
(note is a kind of letter)
'fame' is the second definition.
(I've seen this in another clue)
(Other definitions for note that I've seen before include "Short personal letter" , "Take this to heed" , "Pay close attention to" , "Observe in Eton" , "Do, re or mi?" .)