Lettuce from Nicosia (3)
I believe the answer is:
cos
'lettuce' is the definition.
(cos is a kind of lettuce)
'from nicosia' is the wordplay.
'from' indicates the answer is hidden within the clue.
'COS' is hidden within 'nicosia'.
(Other definitions for cos that I've seen before include "Kind of lettuce in microcosm" , "naturally having longer leaves than most" , "holiday destination" , "Casual as" , "providing unsatisfactory explanation?" .)