Liaison of blonde chasing footballers from the East (6)
I believe the answer is:
affair
'liaison' is the definition.
('affair' can be a synonym of 'liaison')
'blonde chasing footballers from the east' is the wordplay.
'blonde' becomes 'fair' ('fair' can be similar in meaning to 'blonde').
'chasing' is a charade indicator (letters next to each other).
'footballers' becomes 'fa' (Football Association abbreviation).
'from the east' shows that the letters should be reversed in order.
'fa' in reverse letter order is 'af'.
'fair' put after 'af' is 'AFFAIR'.
'of' acts as a link.
(Other definitions for affair that I've seen before include "Romantic relationship, perhaps illicit" , "Secret liaison" , "Subject" , "Secret sexual relationship" , "Illicit liaison" .)