Lie again, by the way (4)
I believe the answer is:
rest
'lie' is the definition.
(synonyms)
'again by the way' is the wordplay.
'again' becomes 're'.
'by' means one lot of letters go next to another.
'the way' becomes 'st'.
're'+'st'='REST'
(Other definitions for rest that I've seen before include "Settle" , "Others; cease work" , "Relaxation" , "Remainder; relax" , "Take it easy, have a break" .)