Life's work (6)
'life's work' is the definition.
(someone's work or profession)
This is all the clue.
(Other definitions for career that I've seen before include "Rush headlong" , "Go at top speed through a working life?" , "Life's work path" , "History of working life (6)" , "series of jobs" .)
(Other definitions for calling that I've seen before include "Ringing" , "Predicting the outcome" , "Vocation or profession" , "Urge to follow a particular career" , "visiting" .)