Lifted, first prize (3)
I believe the answer is:
pot
'prize' is the definition.
(as in a jackpot)
'lifted first' is the wordplay.
'lifted' says the letters should be written backwards (going up in down clue).
'first' becomes 'top' (top can mean the best or first).
'top' in reverse letter order is 'POT'.
(Other definitions for pot that I've seen before include "Grass" , "Plant holder" , "Kitchen utensil or slang cannabis" , "Cannabis; sink (snooker)" , "Receptacle" .)