Lighten large frame in studio (5)
I believe the answer is:
easel
'frame in studio' is the definition.
'lighten large' is the wordplay.
'lighten' becomes 'ease'.
'large' becomes 'l'.
'ease'+'l'='EASEL'
(Other definitions for easel that I've seen before include "Tripod supporting a canvas" , "Supporter for the artist" , "Support in the studio" , "The rest of artists" , "Picture support" .)