Like a picture frame picked up, perhaps, with no fuss (6)
I believe the answer is:
easily
'picture frame picked up perhaps with no fuss' is the definition.
I can't judge whether this defines the answer.
'like a' is the wordplay.
I cannot really see how this works, but
'like' could be 'ly' ('ly' can be similar in meaning to 'like') and 'ly' is found in the answer.
'a' is present in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for easily that I've seen before include "Simply" , "Comfortably" , "no problem!" , "Without difficulty or effort" , "with little effort" .)