Like a type of estate in trouble south of river (10)
I believe the answer is:
industrial
'like a type of estate' is the definition.
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for industrial that I've seen before include "Involved in manufacture" , "Like some business" , "fabricating things?" , "plants may be so described" , "Rapid social changes, starting in Britain from about 1760" .)