Like the main cocaine supply (7)
I believe the answer is:
oceanic
'like the main' is the definition.
(I've seen this before)
'cocaine supply' is the wordplay.
'supply' indicates an anagram (in a supple way).
'cocaine' anagrammed gives 'OCEANIC'.
(Other definitions for oceanic that I've seen before include "In deep water" , "Like the main" , "overwhelming" , "Huge" , "Relating to great seas" .)