Like ultra-spiritual type that offers response to disease? (8)
I believe the answer is:
antibody
'that offers response to disease?' is the definition.
(antibodies fight against diseases)
I don't understand the remainder of the clue.
(Other definitions for antibody that I've seen before include "Protective protein in blood which destroys inimical substances" , "Antigen attacker" , "Fighter in blood" , "personal protection" , "protection against disease" .)