Listless setter in nude, unusually (12)
I believe the answer is:
uninterested
'listless' is the definition.
(thesaurus)
'setter in nude unusually' is the wordplay.
'unusually' indicates anagramming the letters.
'setter'+'in'+'nude'='setterinnude'
'setterinnude' with letters rearranged gives 'UNINTERESTED'.
(Other definitions for uninterested that I've seen before include "Apathetic" , "Not concerned" , "indifferent" , "Bored" .)