Listlessness embodied by drunken nuisance (5)
I believe the answer is:
ennui
'listlessness' is the definition.
(I've seen this in another clue)
'embodied by drunken nuisance' is the wordplay.
'embodied by' indicates the answer is hidden within the clue.
'ENNUI' can be found hidden inside 'drunken nuisance'.
(Other definitions for ennui that I've seen before include "Feeling of disaffection" , "Weariness with life" , "World-weariness" , "Feeling of weariness or boredom" , "Boredom, languor" .)