Little creature in quarantine (3)
I believe the answer is:
ant
'little creature' is the definition.
'in quarantine' is the wordplay.
'in' says the answer is hidden in the clue.
'ANT' can be found hidden inside 'quarantine'.
(Other definitions for ant that I've seen before include "One working hard" , "Emmet or pismire" , "one living in colonies" , "The insect lives in a social colony" , "Worker on the hill" .)