Little food? That makes one cry (6)
I believe the answer is:
weepie
'makes one cry' is the definition.
I know nothing about this answer so I can't judge whether this works.
'little food?' is the wordplay.
'little' becomes 'wee' (similar in meaning).
'food?' becomes 'pie' (pie is a kind of food).
'wee'+'pie'='WEEPIE'
'that' acts as a link.
Can you help me to learn more?
(Other definitions for weepie that I've seen before include "Sentimental film (colloq.)" , "may be enjoyed in cinema" , "is sad to see" , "sloppy work" , "Novel type" .)