Little girl and niece played card game (8)
I believe the answer is:
patience
'card game' is the definition.
(I know that patience is a type of card game)
'little girl and niece played' is the wordplay.
'little girl' becomes 'pat' (I am not sure about the 'little' bit.).
'and' is a charade indicator (letters next to each other).
'played' is an anagram indicator (letters playing around).
'niece' is an anagram of 'ience'.
'pat'+'ience'='PATIENCE'
Can you help me to learn more?
(Other definitions for patience that I've seen before include "Work by G&S" , "Musical work" , "Quality of endurance in operetta" , "bird, some might say" , "Waiting calmly" .)