Little woman on the bottle is cheerful (6)
I believe the answer is:
jovial
'cheerful' is the definition.
(I've seen this before)
'little woman on the bottle' is the wordplay.
'little woman' becomes 'jo' (character from Little Women).
'on' is a charade indicator (letters next to each other).
'the bottle' becomes 'vial' (vial is a kind of bottle).
'jo'+'vial'='JOVIAL'
'is' acts as a link.
(Other definitions for jovial that I've seen before include "Full of cheerful good humour" , "'Jolly, merry (6)'" , "Good-humoured, cheerful" , "Genial, joyous" , "Cheerful, lively" .)