Loaded and left port (5)
I believe the answer is:
laden
'loaded' is the definition.
('laden' can be a synonym of 'loaded')
'left port' is the wordplay.
'left' becomes 'l' (common abbreviation).
'port' becomes 'aden' (I've seen this before**).
'l'+'aden'='LADEN'
'and' acts as a link.
(Other definitions for laden that I've seen before include "bearing burden" , "cargo aboard" , "Freighted" , "Carrying a load" , "full cargo ship" .)