Loaded gun's first removed from convict hideout (5)
I believe the answer is:
laden
'loaded' is the definition.
(synonyms)
'gun's first removed from convict hideout' is the wordplay.
'gun's first' becomes 'g' (1st letter of 'gun').
'removed from' indicates named letters should be taken away.
'convict' becomes 'lag' (slang term for a prisoner).
'hideout' becomes 'den' (synonyms).
'lag' with 'g' removed is 'la'.
'la'+'den'='LADEN'
(Other definitions for laden that I've seen before include "Encumbered" , "'Burdened, oppressed (5)'" , "Burdened, loaded" , "Weighed down with much cargo" , "fully charged" .)