Loathe Manitoba, moving east (9)
I believe the answer is:
abominate
'loathe' is the definition.
(synonyms)
'manitoba moving east' is the wordplay.
'moving' is an anagram indicator (letters are moved around).
'east' becomes 'e' (abbreviation).
'manitoba' is an anagram of 'abominat'.
'abominat'+'e'='ABOMINATE'
(Other definitions for abominate that I've seen before include "Dislike deeply" , "Be revolted by" , "Loathe, detest" , "Amoeba nit - easy to loathe" , "Hate" .)